Live Life Regenerated

Gateway Regenerative Institute is Chicago’s premier destination for regenerative medicine.  

Stop degeneration before it stops you! Regenerative medicine harnesses and amplifies the natural healing processes to stimulate growth and repair.

GRI offers customized, targeted regenerative treatments for a variety of painful conditions. Our treatments include stem cell and PRP injections as well as next generation treatments such as exosomes and alpha 2 macroglobulin injections.


Gateway Regenerative Institute is affiliated with Gateway Spine & Pain Physicians, the largest and most trusted comprehensive independent pain practice in the Chicago region for over 10 years.
Our physicians are passionate about utilizing interventional pain treatments to regenerate lives. Many providers offering regenerative treatments do not possess our level of expertise in performing targeted injections which is needed for effective delivery of many regenerative treatments.
Our physicians are passionate about utilizing interventional pain treatments to regenerate lives. Many providers offering regenerative treatments do not possess our level of expertise in performing targeted injections which is needed for effective delivery of many regenerative treatments.
Gateway Regenerative Institute offers a wide range of regenerative options, not just limited to stem cells. In addition to traditional treatments such as stem cells, platelet rich plasma, and prolotherapy, we are pioneers in the use of next level treatments including exosomes and alpha 2 macroglublin.
Previous slide
Next slide

Conditions We Treat

Spinal Injuries

Joint Injuries

Soft Tissue Injuries



Commonly known as PRP, Platelet-Rich Fibrin Matrix (PRFM) promotes your body’s natural healing abilities by utilizing your own blood platelets to release growth factors. Growth factors are protein molecules found naturally in your body that help stimulate growth and repair by regulating cell growth, preventing cell death, and increasing blood circulation.

A controlled separation process is utilized to create a concentrated platelet solution from your own blood. PRFM takes this solution to the next level through a proprietary step by forming a gel-like substance, or scaffolding, that protects and preserves platelets for injection.


Exosomes are the exciting next advancement in regenerative medicine with vast potential to stimulate healing and repair. Exosomes are naturally occurring vesicles and proteins that are formed within cells, including Mesenchymal Stem Cells (MSCs). When Exosomes exit these cells, they transfer information to neighboring or distant cells much like a delivery truck with GPS. Once they arrive at their destination, they signal cells to regenerate, repair, and heal.

GRI utilizes highly concentrated Exosomes derived from donor placental tissue MSCs. These stem cells secrete potent Exosomes that act powerfully to promote healing.


Stem cells are cells within your body that promote growth, healing, and repair. Stem cells are cells from which other cells are generated. These cells can divide to form more cells of the same type or can differentiate to form other types of cells. Stem cells also secrete Exosomes and growth factors that stimulate repair. Stem cells can be collected from your own body and injected into areas that need repair.


Alpha 2 Macroglobulin (A2M) is an advanced non surgical option for osteoarthritic joint pain and degenerative disc disease. Osteoarthritis is a type of joint disease that results in breakdown of cartilage – the tissue located between the bone of your joints that helps maintain smooth and painless movement. Degeneration of joints and spinal discs commonly lead to debilitating joint and spine pain. A recently discovered, unique biomarker protein called Fibronectin-Aggrecan Complex has been identified in spine discs and joints that are inflamed and painful. A small sample of joint or disc fluid can be sent for analysis. If this biomarker is present, A2M therapy can inhibit the degenerative cascade and promote natural healing by reducing inflammation and further deterioration of your cartilage or discs.


Not only does it surround and protect the fetus as it develops in the mother’s womb, but 100% Pure Amniotic Fluid is rich in nutrients, growth factors and proteins that helps develop the fetus in the womb and supports healing in humans. Amniotic Fluid is offered for therapeutic applications because it contains over 200 growth factors, cytokines and other active peptides beneficial for regenerative tissue repair. Amniotic Fluid products are volunteered from pre-screened, healthy donors who have been thoroughly tested for disease, and obtained during full-term caesarian births.

  • Safe, non-steroidal alternative to surgery
  • Anti-inflammatory and anti-microbial
  • All Natural and drug free
  • Contains more than 200 growth factors
  • Reduced recovery time.


Prolotherapy is a non surgical technique for treating chronic pain around joints and ligaments. It involves injecting small amounts of an irritant such as a sugar solution into those areas.  This causes localized inflammation in the painful structures. As the inflammation resolves, healing occurs which can result in improved stability and decreased pain. These improvements can be maintained long-term after a series of injections.


John K. Hong, MD (Medical Director)

Dr. John K. Hong is the founder and medical director of Gateway Regenerative Institute. He is passionate about helping patients find relief from pain and possibly delaying or avoiding surgery altogether by utilizing regenerative treatments. He is a pioneer in advanced treatments including PRFM, exosomes, and A2M.


At the Chicago Gateway Regenerative Institute our mission is to help you Live Life Regenerated!

For more information or to schedule an appointment, you may provide us your information by clicking the link below and our team will reach out to you. Or you can schedule your appointment by phone at 630-226-1130.

We look forward to providing you an excellent patient experience.


Hinsdale Location
12 Salt Creek Lane, Suite 350 Hinsdale, IL 60521

Other Locations

Bolingbrook Location
329 Remington Blvd, Suite 205
Bolingbrook, IL 60440

Downers Grove Location
3551 Highland Ave, Suite 200A
Downers Grove, IL 60515


Phone: 630-226-1130

© Gateway Regenerative Institute – All Rights Reserved